The match is scheduled to start at 7pm local time (2pm GMT) on Thursday, February 16.
The National Stadium in Karachi will host this fixture.
Karachi Kings lost their first game against Peshawar Zalmi by two runs.
Islamabad United will be playing first match of the PSL 8th edition today against Karachi.
Karachi Kings will be led by allrounder Imad Wasim, and with the franchise experience of James Vince and Matthew Wade in the squad they should be looking at a much more effective batting unit. Adding the bowling credentials of Imran Tahir, the Kings could be on for a much better season after a disappointing start.
Islamabad have pakced their top order with powerhitters and have a reputation for going hard or going home. If Paul Stirling and Colin Munro get into their groove early, a massive score is possible, and Karachi will need to be disciplined in th
James Vince missed the first Karachi Kings game despite having already landed in Pakistan, so it remains to be seen if he is included here.
Islamabad United are without Alex Hales and Rahmanullah Gurbaz.
Karachi Kings: Matthew Wade, James Vince, Sharjeel Khan, Haider Ali, Qasim Akram, Shoaib Malik, Imad Wasim, Andrew Tye, Imran Tahir, Mir Hamza, Mohammad Amir
Paul Stirling, Mohammad Nawaz, Colin Munro, Rassie van der Dussen, Shadab Khan, Azam Khan, Asif Ali, Tom Curran, Faheem Ashraf, Hassan Ali, Mohammad Wasim Jnr
The weather is set to be warm and dry, with temperatures around 24 degrees Celsius.
Islamabad United have a potent top order
Most bookmakers have this one in favour of Islamabad United at 4/6 to win, with Karachi Kings at 6/5.
United have the potential to roll Karachi Kings if the top order fires, but their bowling is not in the best form. Home win.